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Posted on: Aug 23, '08

Thyroid Profile (TPC 3rd Generation)

Thyroid Profile (TPC 3rd Generation)
Triiodothyronine (3,5,3’-L-triiodothyronine, T3) is a hormone that originates from direct thyroid synthesis and
secretion (approximately 20%) and from peripheral conversion of T4 to T3 (approximately 80%). Thyroxine (3,5,3’-Ltetraiodothyronine
T4) is hormone synthesized and secreted by the thyroid gland and plays an important role in
regulating metabolism. TSH is synthesized and secreted by the anterior pituitary in response to a negative feedback
mechanism involving concentrations of FT3 (Free T3) and FT4 (Free T4). Additionally, the hypothalamic tripeptide,
thyrotropin-releasing hormone (TRH), directly stimulates TSH production. TSH is synthesized and secreted by the
anterior pituitary in response to a negative feedback mechanism involving concentrations of FT3 (Free T3) and FT4
(Free T4). The secretion of T3 and T4 is regulated by a negative feedback mechanism involving the thyroid gland,
pituitary gland and hypothalamus. Although serum levels of T3 are small, it has a greater physiological potency than
T4. In the circulation, 99.7% of T3 and 99.95% of T4 is reversibly bound to transport proteins, primarily thyroxinbinding
globulin (TBG) and to a lesser extend albumin and thyroxin-binding prealbumin (TBPA). Unbound or Free T3
and Free T4 are metabolically active and bound T3 and T4 are metabolically inactive, acting as a reserve for Free T3
and Free T4. TBG concentrations remain relatively constant in healthy individuals. However, pregnancy, excess
estrogens, androgens, anabolic steroids and glucocorticoids and known to alter TBG levels and may cause false thyroid
values for thyroid function tests. T3 and T4 levels in these situations may not accurately reflect thyroid status.
Primary malfunction of the thyroid gland may result in excessive (hyper) or below normal (hypo) release of T3 or T4.
In addition, as TSH directly affects thyroid function, malfunction of the pituitary or the hypothalamus influences
the thyroid gland activity. Disease in any portion of the thyroid-pituitary-hypothalamus system may influence the
level of T3 and T4 in the blood. Diagnostically, T3 concentration is more sensitive to certain thyroid conditions
that T4. While T4 levels are a sensitive (and superior) indicator of hypothyroidism, T3 blood levels better define
hyperthyroidism. The ability of quantitiate circulating levels of TSH is important in evaluating thyroid function.
It is especially useful in the differential diagnosis of primary (thyroid) from secondary (pituitary) and tertiary
(hypothalamus) hypothyroidism. In primary hypothyroidism, TSH levels are significantly elevated, while in secondary
and tertiary hypothyroidism, TSH levels are low. In addition, in the Euthyroid Sick Syndrome, multiple alterations
in serum thyroid function test findings have been recognised in patients with a wide variety of nonthyroidal illness
(NTI) without evidence of pre-existing thyroid or hypothalamic-pituitary disease.

Below mentioned are the guidelines for age related reference ranges for T3, T4 and TSH results.

Age Reference Range

Total T3 Total T4 TSH

(In ng/dl) (In µg/dl) (In µlU/ml)

Cord Blood 14 – 86 6.6 – 17.5 2.0 – 40.0

1 – 6 days 100 – 470 11.0 – 21.5 0.4 – 15.0

1 – 3 weeks NA 8.2 – 16.6 0.4 – 10.0

1 week – 1 year 105 – 245 NA NA

1 month – 4 years NA 7.2 – 15.6 0.4 – 5.5

1 – 9 years 94 – 269 NA NA

5 – 9 years NA 6.4 – 13.3 0.4 – 5.5

10 – 20 years 80 – 213 4.2 – 12.6 0.4 – 5.5

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nisha3974 said:
its nice

August 27, '08

manocarla said:
wow good

August 26, '08

lovelyradhy said:
tanx storm u knw am suffering wid same thyriod

August 25, '08

CancerSA said:
Thanks for sharing!

August 25, '08

VintageWine48 said:
Did you know that modern medicine only studies the effects ot the illnesses without really understanding the cause of such illnesses. This is because they are only studying, the flesh, blood, bones and tissues that are mere mud and dust and revert to mud and dust when we die. I believe that modern medicine is heading on the wrong path. Sorry if I have insulted your medical profession.

August 25, '08

Storm39 said:
My experience in medical line:- Physiotherapy with anatomy n physiology- 2year diploma D.P.T, job in a cemist retail counter for 2years, Yogatherapy teachers training with anatomy meditation n body massage 2 years diploma, lab assistance with anatomy n physiology 2years diploma, work in a small laboretory for one year, now working with an N.A.B.L Laboretory 1year 4month runing.

August 24, '08

innocuous2000 said:
Thorough knowledge of a disease.... remarable!!
Are you in medicine?

August 24, '08

naz1988 said:

thanks for sharing this post

August 24, '08

sweetangeljaan said:
thanks...

August 24, '08

kaushik1973vkvip said:
its too good

August 24, '08

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